Silent synapse
نویسندگان
چکیده
منابع مشابه
A silent synapse-based mechanism for cocaine-induced locomotor sensitization.
Locomotor sensitization is a common and robust behavioral alteration in rodents whereby following exposure to abused drugs such as cocaine, the animal becomes significantly more hyperactive in response to an acute drug challenge. Here, we further analyzed the role of cocaine-induced silent synapses in the nucleus accumbens (NAc) shell and their contribution to the development of locomotor sensi...
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A lthough it has long been recognized that steroid hormones primarily exert their effects on neuronal function through their ability to modulate gene transcription in the nucleus (1), an array of physiological and behavioral effects of glucocorticoids have been documented to occur in a fashion that cannot be explained by genomic regulation (2). These findings have prompted the hypothesis that g...
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Exposure to cocaine, and likely other drugs of abuse, generates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-silent glutamatergic synapses in the nucleus accumbens. These immature synaptic contacts evolve after drug withdrawal to redefine the neurocircuital properties. These results raise at least three critical questions: (1) what are the molecular and cellular mechanisms that...
متن کاملDiminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapses.
Neuronal activity regulates the synaptic strength of neuronal networks. However, it is still unclear how diminished activity changes connection patterns in neuronal circuits. To address this issue, we analyzed neuronal connectivity and relevant mechanisms using hippocampal cultures in which developmental synaptogenesis had occurred. We show that diminution of network activity in mature neuronal...
متن کاملNeuronal pentraxins mediate silent synapse conversion in the developing visual system.
Neuronal pentraxins (NPs) are hypothesized to play important roles in the recruitment of AMPA receptors (AMPARs) to immature synapses, yet a physiological role for NPs at nascent synapses in vivo has remained elusive. Here we report that the loss of NP1 and NP2 (NP1/2) leads to a dramatic and specific reduction in AMPAR-mediated transmission at developing visual system synapses. In thalamic sli...
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ژورنال
عنوان ژورنال: Scholarpedia
سال: 2011
ISSN: 1941-6016
DOI: 10.4249/scholarpedia.10705